Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR

X He, S McMahon, TD Henderson, SM Griffey… - PloS one, 2010 - journals.plos.org
Background Ricin (also called RCA-II or RCA60), one of the most potent toxins and
documented bioweapons, is derived from castor beans of Ricinus communis. Several in vitro …

Characterization of Ricin and R. communis Agglutinin Reference Materials

S Worbs, M Skiba, M Söderström, ML Rapinoja… - Toxins, 2015 - mdpi.com
Ricinus communis intoxications have been known for centuries and were attributed to the
toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical …

Broad recognition of ricin toxins prepared from a range of Ricinus cultivars using immunochromatographic tests

P Thullier, G Griffiths - Clinical Toxicology, 2009 - Taylor & Francis
Introduction. It is extremely important that diagnosis of persons exposed to ricin be achieved
in a timely fashion for triage and appropriate treatment. A sensitive and specific …

Recommended immunological assays to screen for ricin-containing samples

S Simon, S Worbs, MA Avondet, DM Tracz, J Dano… - Toxins, 2015 - mdpi.com
Ricin, a toxin from the plant Ricinus communis, is one of the most toxic biological agents
known. Due to its availability, toxicity, ease of production and absence of curative treatments …

Quantification of ricinine in rat and human urine: a biomarker for ricin exposure

RC Johnson, SW Lemire, AR Woolfitt… - Journal of analytical …, 2005 - academic.oup.com
Ricin is a toxalbumin derived from the castor bean plant, Ricinus communis. Ricinine is an
alkaloid (3-cyano-4-methoxy-N-methyl-2-pyridone) that shares a common plant source with …

An international proficiency test to detect, identify and quantify ricin in complex matrices

S Worbs, M Skiba, J Bender, R Zeleny, H Schimmel… - Toxins, 2015 - mdpi.com
While natural intoxications with seeds of Ricinus communis (R. communis) have long been
known, the toxic protein ricin contained in the seeds is of major concern since it attracts …

Detection of intact ricin in crude and purified extracts from castor beans using matrix-assisted laser desorption ionization mass spectrometry

CS Brinkworth, EJ Pigott, DJ Bourne - Analytical chemistry, 2009 - ACS Publications
Ricin is a highly toxic protein from the seeds of the castor bean plant. Crude extracts from
castor beans are toxic by several routes, and there is international concern about the use of …

Characterization of ricin heterogeneity by electrospray mass spectrometry, capillary electrophoresis, and resonant mirror

D Despeyroux, N Walker, M Pearce, M Fisher… - Analytical …, 2000 - Elsevier
Electrospray mass spectrometry (ES/MS), capillary-zone electrophoresis (CZE), capillary
isoelectric focusing (CIEF), and multianalyte resonant mirror are used to evaluate the …

Ricin poisoning: a comprehensive review

J Audi, M Belson, M Patel, J Schier, J Osterloh - Jama, 2005 - jamanetwork.com
ContextThe recent discoveries of ricin, a deadly biologic toxin, at a South Carolina postal
facility, a White House mail facility, and a US senator's office has raised concerns among …

[HTML][HTML] Ricin detection: tracking active toxin

WP Bozza, WH Tolleson, LAR Rosado, B Zhang - Biotechnology advances, 2015 - Elsevier
Ricin is a plant toxin with high bioterrorism potential due to its natural abundance and
potency in inducing cell death. Early detection of the active toxin is essential for developing …