This publication contains the Review Lectures given at a joint NATO Advanced Study
Institute and a FEB S Advanced Study Course, held at Sogesta (Nr. Urbino), Italy from the …

Nucleosides exhibit a broad spectrum of biological activity that generally results from their
ability to inhibit specific enzymes. This activity has led to their use in the development of …

The preceding presentations have served to illustrate the fact that nucleoside analogs vary
widely from each other with respect to the biological systems they can affect and the …

Interest in chemical entities capable of blocking or modifying cell metabolism ultimately goes
back to the discovery of the structure of DNA in the 1950s. Understanding of the biochemical …

Nucleosides are the building blocks required in constructing nucleic acids. As we learned in
school, billions of combinations are possible using only four different nucleosides, and thus …

This is the second of two invited articles reviewing the development of nucleoside analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …

This article provides an overview of the field of nucleoside antiviral agents in so far as they
have some level of current interest. It considers compounds in a number of structural …

This third of four volumes continues the work of its well-received predecessors by providing
comprehensive articles on specific lines of research. All volumes are written with medicinal …

Interest in non-glycosidic derivatives of the nucleo-bases uracil, theymine, cytosine, adenine
and guanine stems from their status as nucleoside analogues. It is noteworty in this …

A general approach to 3', 4'-unsaturated nucleosides (15a-d) is described which proceeds
from a 2'-deoxy-nucleoside uronic acid ester (2a-d, 3, 8) via a facile elimination reaction …