In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer

A Malki, ELA EL SAYED - Anticancer Research, 2014 - ar.iiarjournals.org
Previously, our laboratory reported on novel quinuclidinone derivatives that cause
cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The …

MiR-138-5p improves the chemosensitivity of MDA-MB-231 breast cancer cell line to paclitaxel

M Rasoolnezhad, R Safaralizadeh… - Molecular Biology …, 2023 - Springer
Background Chemotherapy is a predominant strategy for breast cancer (BC) treatment and
paclitaxel (PTX) has been known as a conventional chemotherapeutic drug. However …

Evaluation of the cytotoxic, apoptosis inducing activity and molecular docking of spiroquinazolinone benzamide derivatives in MCF-7 breast cancer cells

M Mahdavi, MM Lavi, R Yekta, MA Moosavi… - Chemico-biological …, 2016 - Elsevier
Previous studies have suggested that quinazolinone derivatives are potent apoptosis-
inducing agents in various cancer cell lines. In the present study, we have investigated …

[HTML][HTML] Anti-cancer effects of pyrazole-platinum (II) complexes combined with anti-MUC1 monoclonal antibody versus monotherapy in DLD-1 and HT-29 colon cancer …

K Supruniuk, R Czarnomysy, A Muszyńska… - Translational …, 2022 - Elsevier
The membrane-bound MUC1 mucin is overexpressed and aberrantly glycosylated in many
epithelium origin cancers. One of the promising strategies in cancer therapy is combining …

A new curcumin analog, CCA-1.1, induces cell cycle arrest and senescence toward ER-positive breast cancer cells.

D NOVITASARI, F WULANDARI… - International …, 2021 - search.ebscohost.com
Abstract We proposed CCA-1.1, one of the curcumin analog derived from PGV-1 to be
explored for anticancer activities toward luminal MCF-7 breast cancer cells, covering on the …

Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis

HL Yang, V Thiyagarajan, PC Shen… - Journal of Experimental …, 2019 - Springer
Background Breast cancer is the most prevalent cancer among women. In triple-negative
breast cancer (TNBC) cells, a novel quinone derivative, coenzyme Q 0 (CoQ 0), promotes …

Characterization of an anti-MUC1 monoclonal antibody with potential as a cancer vaccine

W Qi, BC Schultes, D Liu, M Kuzma… - Hybridoma and …, 2001 - liebertpub.com
The monoclonal antibody (MAb) AR20. 5 is a murine MAb, generated against the tandem
repeat protein backbone of the tumor-associated antigen MUC1. MAb AR20. 5 reacts …

ST09, a novel curcumin derivative, blocks cell migration by inhibiting matrix metalloproteases in breast cancer cells and inhibits tumor progression in EAC mouse …

S Nirgude, R Mahadeva, J Koroth, S Kumar… - Molecules, 2020 - mdpi.com
Purpose: Curcumin is known for its anticancer and migrastatic activity in various cancers,
including breast cancer. Newer curcumin derivatives are being explored to overcome …

[PDF][PDF] MUC1 immunotherapy against a metastatic mammary adenocarcinoma model: Importance of IFN-gamma

CJ Lees, N Smorodinsky, G Horn… - … na naukite i …, 2016 - intapi.sciendo.com
Abstract Immunotherapy using mucin 1 (MUC1) linked to oxidised mannan (MFP) was
investigated in an aggressive MUC1+ metastatic tumour, DA3-MUC1 because, unlike many …

Abstract P1-10-01: Curcumin suppresses MMP-9 expression via inhibition of PKCα/MAPKs and NF-κB/AP-1 activation in MCF-7 cells

SK Kim, YW Kim, HJ Youn, SH Jung - Cancer Research, 2012 - AACR
Background: Curcumin is a polyphenol derived from the plant turmeric (Curcuma longa),
which is commonly used as a spice. It was recently reported for its anticancer effect on …