Chronic bacterial airway infections are the major cause of mortality in cystic fibrosis (CF).
Normal airway defenses include reflex stimulation of submucosal gland mucus secretion by …

Human and pig airway submucosal glands secrete mucus in response to substance P
(SubP), but in pig tracheal glands the response to SubP is> 10-fold greater than in humans …

The mucosa of the proximal airways defends itself and the lower airways from inhaled
irritants such as capsaicinoids, allergens, and infections by several mechanisms. Sensory …

Cystic fibrosis (CF) is caused by dysfunction of the CF transmembrane conductance
regulator (CFTR), an anion channel whose dysfunction leads to chronic bacterial and fungal …

Airway submucosal gland serous cells are sites of expression of the cystic fibrosis
transmembrane conductance regulator (CFTR) and are important for fluid secretion in …

Airway submucosal glands have been proposed as a primary site for initiating and
sustaining airway disease in cystic fibrosis (CF). However, it has been difficult to define the …

Cystic fibrosis (CF) airway disease arises from defective innate defenses, especially
defective mucus clearance of microorganisms. Airway submucosal glands secrete most …

Most airway mucus is produced by submucosal glands in response to neural signals. Gland
mucus traps microbes, inhibits their replication, and clears them from the airways. In cystic …

We are testing the hypothesis that the malfunctioning of airway gland serous cells is a
component of cystic fibrosis (CF) airway disease. CF is caused by mutations that disrupt CF …

Submucosal glands line the cartilaginous airways and produce most of the antimicrobial
mucus that keeps the airways sterile. The glands are defective in cystic fibrosis (CF), but how …