Submucosal glands of the tracheobronchial airways provide the important functions of
secreting mucins, antimicrobial substances, and fluid. This review focuses on the ionic …

The effects have been investigated of the regulatory peptides, substance P (SP) and
bombesin, on the secretion of [14C] glucosamine-labeled trichloroacetic acid …

Human airways and glands express the anion channel cystic fibrosis transmembrane
conductance regulator, CFTR, and the epithelial Na+ channel, ENaC. Cystic fibrosis (CF) …

Airway submucosal gland serous cells express the cystic fibrosis transmembrane
conductance regulator (CFTR) and secrete antimicrobial, anti-inflammatory, and antioxidant …

Our study using feline tracheal isolated submucosal gland preparation has revealed that
substance P (SP) produces an increase in submucosal gland secretion through the actions …

Airway submucosal glands produce the mucus that lines the upper airways to protect them
against insults. This review summarizes evidence for two forms of gland secretion, and …

To elucidate how substance P (SP) produces submucosal gland secretion, we examined the
effects of SP on the glandular contractile response and 3H-labeled glycoconjugate release …

The cystic fibrosis (CF) transmembrane regulator (CFTR) is a cyclic AMP-dependent Cl−
channel that is defective in CF cells. It has been hypothesized that CFTR exhibits an ATP …

Submucosal glands are the major mucus-secreting cells in the tracheobronchial tree, and
they appear to be affected in cystic fibrosis (CF). To study the dysregulation of pulmonary …

It has been proposed that defective submucosal gland function in CF airways is a major
determinant of CF airway disease. We tested the hypothesis that submucosal gland function …