Cystic fibrosis (CF) results from mutations that disrupt CF transmembrane conductance
regulator (CFTR), an anion channel found mainly in apical membranes of epithelial cells. CF …

This study investigated the direct effects of substance P (SP) on ciliary beat frequency of
human upper airway mucosa. Human adenoid explant tissue was maintained in serum free …

The airway is kept sterile by an efficient innate defense mechanism. The cornerstone of
airway defense is mucus containing diverse antimicrobial factors that kill or inactivate …

Protease-activated receptor 2 (PAR2), a G protein-coupled receptor expressed in airway
epithelia and smooth muscle, plays an important role in airway inflammation. In this study …

Fluid and macromolecule secretion by submucosal glands in mammalian airways is
believed to be important in normal airway physiology and in the pathophysiology of cystic …

Sodium 4-phenylbutyrate (PBA), a short-chain fatty acid, has been approved to treat patients
with urea cycle enzyme deficiencies and is being evaluated in the management of sickle cell …

Cystic fibrosis (CF) is caused by mutations in the gene coding for the CF transmembrane
conductance regulator (CFTR). From human normal tracheal submucosal gland cells in …

In adult animals, airway fluid secretion is enhanced reflexly via central nervous system
pathways, and locally mediators such as substance P. To evaluat the role of maturation on …

Airway epithelia are confronted with distinct signals emanating from the luminal and/or
serosal environments. This study tested whether airway epithelia exhibit polarized …

In dogs tracheal secretion is enhanced reflexly and by locally acting mediators such as
substance P (SP). To evaluate the role of these mechanisms on submucosal gland secretion …