Impact of an Adenosine A2A Receptor Agonist and Antagonist on Binding of the Dopamine D2 Receptor Ligand [11C]raclopride in the Rodent Striatum

K Prasad, EFJ de Vries, JWA Sijbesma… - Molecular …, 2022 - ACS Publications
Adenosine A2A and dopamine D2 receptors in the basal ganglia form heterotetrameric
structures that are involved in the regulation of motor activity and neuropsychiatric functions …

Effects of adenosine A2A receptor stimulation in vivo on dopamine D3 receptor agonist binding in the rat brain

M Hillefors, PB Hedlund, G von Euler - Biochemical pharmacology, 1999 - Elsevier
To investigate if adenosine A2A receptor stimulation in vivo modulates dopamine D3
receptor binding, we analyzed the effects of 2-[p-(carboxyethyl)-phenylethylamino]-5′-N …

[HTML][HTML] Effects of the adenosine A2A receptor antagonist KW6002 on the dopaminergic system, motor performance, and neuroinflammation in a rat model of …

K Prasad, EFJ de Vries, E van der Meiden… - …, 2024 - Elsevier
Abstract Adenosine A 2A-receptors (A 2A R) and dopamine D 2-receptors (D 2 R) are known
to work together in a synergistic manner. Inhibiting A 2A Rs by genetic or pharmacological …

Stimulation of adenosine A1 receptors decreases in vivo dopamine D1 receptor binding of [11C]SCH23390 in the cat striatum revealed by positron emission …

Y Sakiyama, K Hatano, T Kato, T Tajima… - Annals of nuclear …, 2007 - Springer
It has been previously suggested that activation of adenosine A 1 receptor modulates
dopamine D 1 receptor binding in vitro, although the direct mechanism of this interaction in …

Effects of CGS 21680 in vivo on dopamine D2 agonist binding in the rat brain

M Hillefors-Berglund, PB Hedlund, G von Euler - Brain research, 1995 - Elsevier
To investigate whether adenosine A2a agonists modulate dopamine D2 receptor binding in
vivo, we have analyzed the effects of intraperitoneally administered 2-[p-(carboxyethyl) …

Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum

Z Díaz-Cabiale, Y Hurd, D Guidolin, UB Finnman… - …, 2001 - journals.lww.com
Abstract Adenosine A2A receptors (A2AR) and dopamine D2 receptors (D2R) are highly
concentrated in the striatum, where they are co-localized and exert reciprocal antagonistic …

Adenosine A2A Receptor-Antagonist/Dopamine D2 Receptor-Agonist Bivalent Ligands as Pharmacological Tools to Detect A2A-D2 Receptor Heteromers

A Soriano, R Ventura, A Molero, R Hoen… - Journal of medicinal …, 2009 - ACS Publications
Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …

[HTML][HTML] Effects of an Adenosine A2A Receptor Antagonist on Striatal Dopamine D2-Type Receptor Availability: A Randomized Control Study Using Positron Emission …

K Okita, K Kato, Y Shigemoto, N Sato… - Frontiers in …, 2021 - frontiersin.org
Introduction: Altered dopaminergic neurotransmission, especially in the functioning of
dopamine D2-type receptors, is considered central to the etiology of a variety of …

Adenosine A1 receptor‐mediated inhibition of dopamine release from rat striatal slices is modulated by D1 dopamine receptors

C O'Neill, BJ Nolan, A Macari… - European Journal of …, 2007 - Wiley Online Library
Dopamine release is regulated by presynaptic dopamine receptors and interactions
between adenosine and dopamine receptors have been well documented. In the present …

Increased in vivo [11C] raclopride binding to brain dopamine receptors in amphetamine-treated rats

MR Kilbourn, EF Domino - European journal of pharmacology, 2011 - Elsevier
The hypothesis that repeated daily doses of amphetamine increases the number of
available dopamine D2 receptors in vivo in rat striatum, and may enhance the response to …