A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders

KG Commons, KR Connolley… - …, 2003 - nature.com
The serotonergic system arising from the dorsal raphe nucleus (DR) has long been
implicated in psychiatric disorders, and is considered one site of action of classical anxiolytic …

Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions

L Pernar, AL Curtis, WW Vale, JE Rivier… - Journal of …, 2004 - Soc Neuroscience
The dorsal raphe (DR)-serotonin (5-HT) system has been implicated in stress-related
psychiatric disorders. Stress may impact on this system through corticotropin-releasing factor …

Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus

LG Kirby, KC Rice, RJ Valentino - Neuropsychopharmacology, 2000 - Elsevier
The present study examined the regional localization of corticotropin-releasing factor (CRF)-
and 5-hydroxytryptamine (5-HT)-immunoreactive (IR) fibers within the rat dorsal raphe …

Anatomic and functional topography of the dorsal raphe nucleus

JK Abrams, PL Johnson, JH Hollis… - Annals of the New York …, 2004 - Wiley Online Library
Serotonergic systems play an important and generalized role in regulation of sleep‐wake
states and behavioral arousal. Recent in vivo electrophysiologic recording studies in …

Molecular and anatomical organization of the dorsal raphe nucleus

KW Huang, NE Ochandarena, AC Philson, M Hyun… - Elife, 2019 - elifesciences.org
The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been
implicated in a wide variety of behavioral and neurological disorders. The DRN is …

Ultrastructural evidence for a role of γ‐aminobutyric acid in mediating the effects of corticotropin‐releasing factor on the rat dorsal raphe serotonin system

M Waselus, RJ Valentino… - Journal of Comparative …, 2005 - Wiley Online Library
The dorsal raphe nucleus (DRN) serotonin (5‐HT) system has been implicated in acute
responses to stress and in stress‐related psychiatric disorders such as anxiety and …

Stress-related serotonergic systems: implications for symptomatology of anxiety and affective disorders

MW Hale, A Shekhar, CA Lowry - Cellular and molecular neurobiology, 2012 - Springer
Previous studies have suggested that serotonergic neurons in the midbrain raphe complex
have a functional topographic organization. Recent studies suggest that stimulation of a bed …

Corticotropin‐releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity

GL Forster, RB Pringle, NJ Mouw… - European Journal of …, 2008 - Wiley Online Library
Interactions between central corticotropin‐releasing factor (CRF) and serotonergic systems
are believed to be important for mediating fear and anxiety behaviors. Recently we …

Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences …

F Lechin, B van der Dijs… - Progress in Neuro …, 2006 - Elsevier
Monoaminergic neurons located in the central nervous system (CNS) are organized into
complex circuits which include noradrenergic (NA), adrenergic (Ad), dopaminergic (DA) …

The dorsal raphe nucleus—from silver stainings to a role in depression

KA Michelsen, C Schmitz, HWM Steinbusch - Brain research reviews, 2007 - Elsevier
Over a hundred years ago, Santiago Ramón y Cajal used a new staining method developed
by Camillo Golgi to visualize, among many other structures, what we today call the dorsal …