Drug combinations have been proposed as a promising therapeutic strategy to overcome
drug resistance and improve efficacy of monotherapy regimens in cancer. This strategy aims …

A promising alternative to address the problem of acquired drug resistance is to rely on
combination therapies. Identification of the right combinations is often accomplished through …

Drug combination therapy is a promising strategy to treat complex diseases such as cancer
and infectious diseases. However, current knowledge of drug combination therapies …

Background Drug combination therapy, which is considered as an alternative to single drug
therapy, can potentially reduce resistance and toxicity, and have synergistic efficacy. As drug …

High-throughput drug screening has facilitated the discovery of drug combinations in cancer.
Many existing studies adopted a full matrix design, aiming for the characterization of drug …

Drug combinations have exhibited promising therapeutic effects in treating cancer patients
with less toxicity and adverse side effects. However, it is infeasible to experimentally screen …

Simple Summary Current treatments for complex diseases, including cancer, are generally
characterized by high toxicity due to their low selectivity for target cells. Moreover, patients …

Complex diseases like cancer are regulated by large, interconnected networks with many
pathways affecting cell proliferation, invasion, and drug resistance. However, current cancer …

Combinational pharmacotherapy with the synergistic/additive effect is a powerful treatment
strategy for complex diseases such as malignancies. Identifying synergistic combinations …

Combinatorial therapy is a promising strategy for combating complex disorders due to
improved efficacy and reduced side effects. However, screening new drug combinations …