Although stress represents the major environmental element of susceptibility for mood
disorders, the relationship between stress and disease remains to be fully established. In the …

Recent findings on stress induced structural plasticity in rodents have identified important
differences between the hippocampus and amygdala. The same chronic immobilization …

In the medial prefrontal cortex, the prelimbic area is emerging as a major modulator of fear
behavior, but the mechanisms remain unclear. Using a selective neocortical knockout …

Brain-derived neurotrophic factor (BDNF) regulates diverse biological functions ranging from
neuronal survival and differentiation during development to synaptic plasticity and cognitive …

BACKGROUND: Indirect evidence suggests that loss of brain-derived neurotrophic factor
(BDNF) from forebrain regions contributes to an individual's vulnerability for depression …

Neurotrophic factors are critical regulators of the formation and plasticity of neuronal
networks. Brain-derived neurotrophic factor (BDNF) is abundant in the brain and periphery …

There are significant sex differences in vulnerability to develop fear-related anxiety
disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males …

Brain-derived neurotrophic factor (BDNF) is widely accepted as being critical for neural and
synaptic plasticity throughout the nervous system. Recent work has shown that BDNF in the …

Understanding the etiology and pathogenesis schizophrenia and depression is a major
challenge facing psychiatry. One hypothesis is that these disorders are secondary to a …

According to the “neurotrophin hypothesis”, brain-derived neurotrophic factor (BDNF) is an
important candidate gene in depression. Moreover, environmental stress is known to …