Blood clotting is a finely regulated process that is essential for hemostasis. However, when
dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are …

Chemoattractant cytokines or chemokines constitute a family of structurally related proteins
found in vertebrates, bacteria, or viruses. So far, 48 chemokine genes have been identified …

Undoubtedly, platelets are key elements in the regulation of thrombosis and haemostasis.
Along with their primary task to prevent blood loss from injured vessels, platelets have …

Thrombosis is an important clinical entity, and pathologic thrombosis, in the form of
atherosclerosis, is a major cause of morbidity and mortality. Recent research points to the …

Platelets are a rich source of different chemokines and express chemokine receptors.
CXCL4 is highly abundant in platelets and involved in promoting monocyte arrest from …

Blood platelets play critical roles in hemostasis, providing rapid essential protection against
bleeding and catalyzing the important slower formation of stable blood clots via the …

Chemokines encompass a large family of proteins that act as chemoattractants and are
involved in many biological processes. In particular, chemokines guide the migration of …

Chemokines are a family of small heparin-binding proteins, mostly known for their role in
inflammation and immune surveillance, which have emerged as important regulators of …

To fulfil its orchestration of immune cell trafficking, a network of chemokines and receptors
developed that capitalizes on specificity, redundancy, and functional selectivity. The …

In recent years, it has become clear that platelets and platelet-derived chemokines, beyond
their role in thrombosis and haemostasis, are important mediators affecting a broad …