The brain plays a key role in the controls of energy intake and expenditure, and many genes
associated with obesity are expressed in the central nervous system. Technological and …

The new lifestyle in the modern world is causing a rapid increase in the prevalence of
obesity and associated health problems. Increased availability of palatable and energy …

A neural network sensitive to leptin and other energy status signals stretching from the
hypothalamus to the caudal medulla has been identified as the homeostatic control system …

The brain responds to macronutrients via intricate mechanisms. We review how the brain's
neural systems implicated in homeostatic control of feeding and hedonic responses are …

Ever since the pioneering discoveries in the mid nineteen hundreds, the hypothalamus was
recognized as a crucial component of the neural system controlling appetite and energy …

Food intake and energy expenditure are key regulators of body weight. To regulate food
intake, the brain must integrate physiological signals and hedonic cues. The brain plays an …

Abstract Purpose of Review This review examines the food addiction model and the role of
food hedonic pathways in the pathogenesis and treatment of obesity. Recent Findings The …

Since the late 1970s obesity prevalence and per capita food intake in the USA have
increased dramatically. Understanding the mechanisms underlying the hyperphagia that …

Food intake regulation in humans is a complex process controlled by the dynamic
interaction of homeostatic and hedonic systems. Homeostatic regulation is controlled by …

Obesity is on the rise in all developed countries, and a large part of this epidemic has been
attributed to excess caloric intake, induced by ever present food cues and the easy …