Phagosome-lysosome fusion in innate immune cells like macrophages and neutrophils
marshal an essential role in eliminating intracellular microorganisms. In microbe-challenged …

Mycobacterium tuberculosis is an intracellular bacterium that can survive within
macrophages. Such survival is potentially associated with Coronin‐1a (Coro1a). We …

Mycobacterium tuberculosis when phagocytosed by macrophages is not cleared completely
and many of the bacteria remain in phagosomes indefinitely. In this study we considered …

Pathogenic mycobacteria survive within macrophages by avoiding lysosomal delivery,
instead residing in mycobacterial phagosomes. Upon infection, the leukocyte-specific …

Macrophages being the connecting link between innate and adaptive immune system plays
a crucial role in microbial antigen presentation and orchestrates the subsequent clearance …

Mycobacterium tuberculosis evades the innate antimicrobial defenses of macrophages by
inhibiting the maturation of its phagosome to a bactericidal phagolysosome. Despite intense …

Macrophages are crucial for innate immunity, apoptosis, and tissue remodeling, processes
that rely on the capacity of macrophages to internalize and process cargo through …

Microbes have interacted with eukaryotic cells for as long as they have been co-existing.
While many of these interactions are beneficial for both the microbe as well as the eukaryotic …

There are many different pathogenic stimuli that are able to activate the immune system,
ranging from microbes that include bacteria, viruses, fungi, and parasites to host-derived …

Alveolar macrophages are the lung's first line of defense against infection by pathogenic
microbes. Despite this, Mycobacterium tuberculosis can proliferate in alveolar macrophages …