A review of the current literature and a guide to the early diagnosis of autoimmune disorders associated with neuromyelitis optica
A Iyer, L Elsone, R Appleton, A Jacob - Autoimmunity, 2014 - Taylor & Francis
Neuromyelitis optica (NMO) is an immune-mediated neurological disorder characterised by
recurrent episodes of optic neuritis and longitudinally extensive transverse myelitis. A serum …
recurrent episodes of optic neuritis and longitudinally extensive transverse myelitis. A serum …
Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study
Importance Most patients with neuromyelitis optica (NMO) and many with NMO spectrum
disorder have autoantibodies against aquaporin-4 (AQP4-Abs), but recently, myelin …
disorder have autoantibodies against aquaporin-4 (AQP4-Abs), but recently, myelin …
Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis
BACKGROUND: Antibodies to aquaporin-4 (AQP4-Ab) are found in 60–80% of patients with
neuromyelitis optica (NMO), a severely disabling inflammatory CNS disorder of putative …
neuromyelitis optica (NMO), a severely disabling inflammatory CNS disorder of putative …
Aquaporin 4 and neuromyelitis optica
MC Papadopoulos, AS Verkman - The Lancet Neurology, 2012 - thelancet.com
Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …
Neuromyelitis optica spectrum disorders: spectrum of MR imaging findings and their differential diagnosis
Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder for which the
aquaporin-4 (AQP4) water channels are the major target antigens. Advances in the …
aquaporin-4 (AQP4) water channels are the major target antigens. Advances in the …
Aquaporin-4 antibody–positive cases beyond current diagnostic criteria for NMO spectrum disorders
Objectives: To analyze aquaporin-4 (AQP4) antibody–positive patients who do not fulfill the
current diagnostic criteria of neuromyelitis optica (NMO) and NMO spectrum disorders …
current diagnostic criteria of neuromyelitis optica (NMO) and NMO spectrum disorders …
Characteristic brain magnetic resonance imaging abnormalities in central nervous system aquaporin-4 autoimmunity
W Kim, MS Park, SH Lee, SH Kim… - Multiple Sclerosis …, 2010 - journals.sagepub.com
Background: Although neuromyelitis optica has been traditionally regarded as a disease
without brain involvement, brain abnormalities are not uncommon in patients with …
without brain involvement, brain abnormalities are not uncommon in patients with …
Anti–Aquaporin‐4 monoclonal antibody blocker therapy for neuromyelitis optica
Objective: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the
central nervous system. Circulating autoantibodies (NMO‐immunoglobulin [Ig] G) against …
central nervous system. Circulating autoantibodies (NMO‐immunoglobulin [Ig] G) against …
Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: a multicentre study of 175 patients
S Jarius, K Ruprecht, B Wildemann, T Kuempfel… - Journal of …, 2012 - Springer
Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4
(AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been …
(AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been …
Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema
J Ratelade, JL Bennett, AS Verkman - PloS one, 2011 - journals.plos.org
The pathogenesis of neuromyelitis optica (NMO) involves binding of IgG autoantibodies
(NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system (CNS). We …
(NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system (CNS). We …