Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Highlights•Neutrophils are increasingly recognized as multi-faceted immune cells.•In aged
hosts, neutrophils show inaccurate chemotaxis and reduced NET formation.•Neutrophils …

Despite increasing longevity, many old people are not in good health. There has been an
increase in the prevalence of age-associated multi-morbidity (two or more chronic conditions …

Human neutrophils are activated by a wide array of compounds through their receptors. This
elicits their classical functions, such as chemotaxis, phagocytosis, and the production of …

Impaired immune function has been implicated in the declining health and higher incidence
of cancer in the elderly. However, age-related changes to immunity are not completely …

Neutrophils are first-responders, providing early protection against invading pathogens.
Recent findings have revealed a temporal dimension to neutrophil function, associated with …

Under steady-state conditions, aged neutrophils are removed from the circulation in bone
marrow, liver, and spleen, thereby maintaining myeloid cell homeostasis. The fate of these …

Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

As humans age, their morbidity and mortality from infection increases, their response to
vaccination declines and they have an increased incidence of inflammatory diseases and …

Tumor necrosis factor (TNF), a potent inflammatory cytokine, and mitochondrial DNA
(mtDNA), a product of inflammation-induced tissue damage, increase with age …