Diabetes mellitus disrupts wound repair and leads to the development of chronic wounds,
likely due to impaired angiogenesis. We previously demonstrated that human proinsulin C …

Excessive proliferation of vascular smooth muscle cells (VSMCs) is one of the primary
lesions in atherosclerosis development during diabetes. High glucose triggers VSMC …

Aim Recent studies have demonstrated that C-peptide is biologically active and might have
a beneficial effect on late complications in diabetes mellitus. The aim of this study was to …

Hyperglycemia is considered to be the major cause of microvascular complications of
diabetes. Growing evidence highlights the importance of hyperglycemia‐mediated …

Reestablishment of the structural and functional microvasculature would be beneficial to
promote healing of diabetic wounds. We explored the role of insulin application on …

The proinsulin connecting peptide, C-peptide, is a cleavage product of insulin synthesis that
is co-secreted with insulin by pancreatic β-cells following glucose stimulation. Recombinant …

Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to
develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show …

Atherosclerosis is well known as an inflammatory disease that can lead to clinical
complications such as heart attack or stroke. C‐peptide as a cleavage product of proinsulin …

A major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia),
resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause …

Background Impaired wound healing is a major complication associated with diabetes,
involving a dysregulation and impairments in the inflammatory and angiogenic phases of …