Targeted chemotherapy for cancer treatment offers a great potential advantage in tumour
treatment due to greater specificity of delivery which leads to increased dose of the cytotoxin …

The vitamin folic acid (FA) enters cells either through a carrier protein, termed the reduced
folate carrier, or via receptor-mediated endocytosis facilitated by the folate receptor (FR) …

An efficient mechanism-based tumor-targeting drug delivery system, based on tumor-
specific vitamin-receptor mediated endocytosis, has been developed. The tumor-targeting …

1.1. General Strategies in the Design of Tumor Targeted Therapeutics. Today's quest for
developing tumor-targeted therapies has naturally followed two nonoverlapping strategies …

Rapidly growing cells show an increased demand for nutrients and vitamins. The objective
of our work is to exploit the supply route of vitamin B12 to deliver new derivatives of this vital …

The covalent attachment of the vitamin folic acid to almost any molecule yields a conjugate
that can be endocytosed into folate receptor-bearing cells. Because folate receptors are …

The membrane-bound folate receptor (FR) is overexpressed on a wide range of human
cancers, such as those originating in ovary, lung, breast, endometrium, kidney and brain …

Active targeting can improve the retention of drugs and drug delivery systems in tumors,
thereby enhancing their therapeutic efficacy. In this context, vitamin receptors that are …

The receptor for the vitamin, folic acid, is overexpressed on a number of human tumors,
including cancers of the ovary, kidney, uterus, testis, brain, colon, lung, and myelocytic blood …

Cancer therapies that exploit targeting ligands to deliver attached cytotoxic drugs selectively
to malignant cells are currently receiving significant attention. While antibody-targeted drugs …