Interleukin-15 in autoimmunity
H Allard-Chamard, HK Mishra, M Nandi, M Mayhue… - Cytokine, 2020 - Elsevier
Abstract Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …
Interleukin-15: a new cytokine target for the treatment of inflammatory diseases
IB McInnes, JA Gracie - Current opinion in pharmacology, 2004 - Elsevier
Interleukin (IL)-15 is a pleiotropic pro-inflammatory cytokine that is expressed in several
inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary …
inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary …
Interleukin 15: its role in inflammation and immunity
LP Perera - Inflammation, 2001 - Springer
Abstract Interleukin 15 (IL-15) is a 14–15 kDa polypeptide that belongs to the 4 α-helix-
bundle family of cytokines and was originally discovered due to its T cell proliferative activity …
bundle family of cytokines and was originally discovered due to its T cell proliferative activity …
Interleukin 15: biology and relevance to human disease
TA Fehniger, MA Caligiuri - Blood, The Journal of the American …, 2001 - ashpublications.org
Since the cloning of interleukin (IL)-15 six years ago, there have been numerous studies
examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar …
examining the molecular and cellular biology of this cytokine. IL-15 and IL-2 have similar …
Interleukin 15: A key cytokine for immunotherapy
Abstract Interleukin (IL)-15, a member of the immunoregulatory cytokines family, is a
pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid …
pluripotent molecule with therapeutic potential. It is predominantly expressed by the myeloid …
Interleukin-15 and its role in chronic inflammatory diseases
I Kirman, B Vainer, OH Nielsen - Inflammation Research, 1998 - Springer
This review focuses on the biological effects of the newly discovered cytokine, interleukin 15
(IL-15), in chronic inflammatory disorders. IL-15 shares biological activities with IL-2, and like …
(IL-15), in chronic inflammatory disorders. IL-15 shares biological activities with IL-2, and like …
The sushi domain of soluble IL-15 receptor α is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo
IL-15 is a pleiotropic cytokine that plays important roles in both innate and adaptive
immunity. It is associated with a range of immunopathology, including rheumatoid arthritis …
immunity. It is associated with a range of immunopathology, including rheumatoid arthritis …
Emerging roles for IL-15 in the activation and function of T-cells during immune stimulation
SM Anthony, KS Schluns - Research and Reports in Biology, 2015 - Taylor & Francis
Interleukin (IL)-15 is a cytokine that promotes the development and homeostasis of a group
of lymphocytes; however, IL-15 is also significantly upregulated in response to pathogen …
of lymphocytes; however, IL-15 is also significantly upregulated in response to pathogen …
Role of IL-15 in immune-mediated and infectious diseases
A Di Sabatino, SA Calarota, F Vidali… - Cytokine & growth factor …, 2011 - Elsevier
IL-15 has a broad spectrum of biological activities. It is crucial for the development,
proliferation, survival and differentiation of multiple cells from both innate and adaptive …
proliferation, survival and differentiation of multiple cells from both innate and adaptive …
Targeting IL-17 in autoimmunity and inflammation
The discovery of two distinct subsets of helper T cells, IFN-γ-producing Th1 cells and IL-4-
producing Th2 cells, about three decades ago enabled us to understand the …
producing Th2 cells, about three decades ago enabled us to understand the …