Receptors are macromolecules in or on cells that me-diate physiological responses upon
bindingspecific ligands. Over the past few years, important advances have been made in the …

During the past few years considerable progress has been made in the study, identification,
isolation, and purification of a variety of membrane-localized receptors. The general …

Since the earliest pharmacological studies, the cell membrane has been considered a likely
site of drug interaction (Clark, 1933). Yet only within the past decade has considerable …

Publisher Summary This chapter discusses the problems in the study of hormone receptors
and their modulation of membrane function. Because physiological membrane receptors are …

Receptors for peptide hormones and neurotransmitters are integral components of the
plasma membrane of cells which serve to couple the external milieu to the intracellular …

Many hormones, neurotransmitters, drugs, and cellular toxins initiate their ac-tion via specific
interactions with plasma membrane receptors. It is particularly striking how important the in …

Hormones are a group of compounds secreted by certain organs or cells into the circulation
which act to coordinate and regulate the metabolic processes of other cells. The hormones …

The rapid advance in the understanding of the receptor mediated mechanisms, whereby a
variety of drugs, hormones and toxins act at the cell membrane, can be attributed in large …

Hardly a decade ago, membrane receptors were an attractive but largely unproven concept.
Since that time enormous progress has been made, and we are now able to consider …