Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue.

MH Hanigan, HF Frierson Jr - Journal of Histochemistry & …, 1996 - journals.sagepub.com
We developed a new, highly specific antibody that localizes gamma-glutamyl transpeptidase
(GGT) in formalin-fixed sections of human tissue. The specificity of the antibody, GGT129, is …

Altered expression of gamma-glutamyl transpeptidase in human tumors

MH Hanigan, HF Frierson Jr, PE Swanson… - Human pathology, 1999 - Elsevier
Elevated levels of gamma-glutamyl transpeptidase (GGT) activity and intracellular
glutathione in tumor cells have been correlated with resistance to several classes of …

Human γ-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat

DC Goodspeed, TJ Dunn, CD Miller, HC Pitot - Gene, 1989 - Elsevier
Abstract γ-Glutamyl transpeptidase (GGT) is a glutathione-metabolizing enzyme that has
been extensively studied in relation to hepatocarcinogenesis. Using a cDNA for rat kidney …

Localization and significance of γ-glutamyltranspeptidase in normal and neoplastic mouse skin

LM De Young, WL Richards, W Bonzelet, LL Tsai… - Cancer research, 1978 - AACR
The suggestion that elevated γ-glutamyltranspeptidase (GGT) activity could be a marker for
hepatic neoplasia has prompted us to investigate the role of this enzyme in normal and …

[PDF][PDF] Gamma-glutamyl transpeptidase–its role in hepatocarcinogenesis

MH Hanigan, HC Pitot - Carcinogenesis, 1985 - academia.edu
The enzyme gamma-glutamyl transpeptidase (GGT)* is widely used as a marker in
preneoplastic lesions in the liver during chemical carcinogenesis (1). The discovery of a link …

γ-Glutamyltranspeptidase: a tumour cell marker with a pharmacological function

M Vanderlaan, W Phares - The Histochemical Journal, 1981 - Springer
The distribution of γ-glutamyltranspeptidase activity (γGT) in adult, foetal, and neoplastic
tissues in rats and humans is reviewed. The normal adult kidney, pancreas, and jejunum are …

γ-Glutamyl transpeptidase, a glutathionase: its expression and function in carcinogenesis

MH Hanigan - Chemico-biological interactions, 1998 - Elsevier
γ-Glutamyl transpeptidase (GGT) is found throughout the plant and animal kingdoms. It is a
cell surface glycoprotein that cleaves γ-glutamyl amide bonds. The most abundant …

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

E Rajpert-De Meyts, N Heisterkamp… - Proceedings of the …, 1988 - National Acad Sciences
We have identified the gene for human gamma-glutamyl transpeptidase [GGT; glutamine: D-
glutamyl-peptide 5-glutamyltransferase (also called gamma-glutamyltransferase), EC 2.3 …

Human Ovarian Tumors Express γ-Glutamyl Transpeptidase

MH Hanigan, HF Frierson Jr, JE Brown, MA Lovell… - Cancer Research, 1994 - AACR
Gamma-glutamyl transpeptidase (GGT) is a cell surface enzyme that initiates the cleavage of
extracellular glutathione, thereby providing the cell with the amino acids necessary for …

gamma-Glutamyl transpeptidase: a single copy gene in the rat and a multigene family in the human genome.

A Pawlak, O Lahuna, F Bulle, A Suzuki, N Ferry… - Journal of Biological …, 1988 - Elsevier
gamma-Glutamyl transpeptidase (GGT) genomic sequences were isolated from rat and
human libraries using a rat GGT cDNA as a cross-species hybridization probe …