Background Dysfunction of p53 is a key cause of cancer development, while CCDC106 can
reduce p53 stability and is associated with lung cancer. However, the roles of CCDC106 in …

Cell division cycle 48 (CDC48), a ubiquitin-dependent molecular chaperone, is thought to
mediate a variety of degradative and regulatory processes and maintain cellular …

Known activities of the ubiquitin‐selective AAA ATPase Cdc48 (p97) require one of the
mutually exclusive cofactors Ufd1/Npl4 and Shp1 (p47). Whereas Ufd1/Npl4 recruits Cdc48 …

Ubiquitin-dependent molecular chaperone p97, also known as valosin-containing protein
(VCP) or Cdc48, is an AAA ATPase involved in protein turnover and degradation. p97 …

The ubiquitin-dependent chaperone Cdc48 (cell divison cycle 48)/p97 is involved in a
variety of degradative and regulatory processes during interphase that help to maintain …

Members of the cdc25 family are protein phosphatases that play pivotal roles in cell cycle
progression. Cdc25A has been shown to be a critical regulator of the G1/S transition of …

Valosin-containing protein, VCP/p97 or Cdc48, is a eukaryotic ATPase involved in
membrane fusion, protein transport, and protein degradation. We describe two proteins …

The ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important
cellular processes such as protein quality control, organellar homeostasis, and DNA …

The anaphase‐promoting complex/cyclosome (APC/C) ubiquitin ligase is tightly regulated to
ensure programmed proteolysis in cells. The activity of the APC/C is positively controlled by …

Abstract The dual specificity (Tyr/Thr) phosphatase Cdc25A activates cyclin-dependent
kinases (Cdks) to promote cell-cycle progression and has significant oncogenic potential …