Cdc34 is an E2-conjugating enzyme required for catalyzing the polyubiquitination reaction
mediated by the Skp1· CUL1· F-box (SCF) protein E3 ubiquitin (Ub) ligase. Here, we show …

A conserved AAA+ ATPase, called Cdc48 in yeast and p97 or VCP in metazoans, plays an
essential role in many cellular processes by segregating polyubiquitinated proteins from …

In budding (Saccharomyces cerevisiae) and fission (Schizosaccharomyces pombe) yeast
and other unicellular organisms, DNA damage and other stimuli can induce cell death …

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal
dementia (IBMPFD) is a dominantly inherited degenerative disorder caused by mutations in …

Cell division cycle protein 20 (Cdc20) is a member of the cell cyclin family. In the early stage
of mitosis, it activates the anaphase-promoting complex (APC) and forms the E3 ubiquitin …

Abstract The Rho family of GTPases represents a class of Ras-related signaling molecules
often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP …

In eukaryotic cells, control mechanisms of cell-cycle progression have evolved to accurately
monitor the integrity of genetic information to be transferred to the progeny. Cdc25A …

Abstract p97 (also known as Cdc48, Ter94, and VCP) is an essential, abundant and highly
conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes. Even though …

ABSTRACT A number of lines of evidence have suggested a possible involvement of the
mitosis-promoting protein kinase Cdc2 in the process of apoptotic cell death, and one recent …

The initiation of apoptosis in response to the disruption of mitosis provides surveillance
against chromosome instability. Here, we show that proteolytic destruction of the key …