CDC42, a Ras-related small GTP binding protein, is involved in diverse cellular functions in
lymphocytes. We generated transgenic mice expressing constitutively active murine CDC42 …

ABSTRACT A number of lines of evidence have suggested a possible involvement of the
mitosis-promoting protein kinase Cdc2 in the process of apoptotic cell death, and one recent …

Background CDC27 is one of the core components of Anaphase Promoting
complex/cyclosome. The main role of this protein is defined at cellular division to control cell …

Human Cdc14A is an evolutionary conserved dual-specificity protein phosphatase that
reverses the modifications effected by cyclin-dependent kinases and plays an important role …

Background The evolutionary conserved cyclin-dependent kinase phosphatase hCdc14A
has been shown to play potential roles in the regulation of mitotic exit and in the centrosome …

VCP (also known as p97 or Cdc48p in yeast) is an AAA+ ATPase regulating endoplasmic
reticulum–associated degradation. After high-throughput screening, we developed …

E-type cyclins (E1 and E2) regulate the S phase program in the mammalian cell division
cycle. Expression of cyclin E1 and E2 is frequently deregulated in a variety of cancer types …

Selected antiapoptotic genes were expressed in baker's yeast (Saccharomyces cerevisiae)
to evaluate cytoprotective effects during oxidative stress. When exposed to treatments …

VCP/p97/Cdc48, a member of the ATPases associated with diverse cellular activities (AAA)
family, is necessary for the endoplasmic-reticulum-associated protein degradation (ERAD) …

In the last few years dysregulated expression of the cell surface glycoprotein CUB domain‐
containing protein 1 (CDCP1) has been associated with several cancers and this cell …