Cdc25B phosphatases function as key players in G2/M cell cycle progression by activating
the CDK1–cyclinB1 complexes. They also have an essential role in recovery from the G2/M …

Ubiquitin-dependent protein degradation usually involves escort factors that target
ubiquitylated substrates to the proteasome. A central element in a major escort pathway is …

The Cdc25 family of protein phosphatases positively regulates cell division by activating
cyclin-dependent protein kinases (CDKs). In humans and rodents, there are three Cdc25 …

Current evidence suggests that CDC25A is not only a major regulator of both G1/S and
G2/M transition during unperturbed cell cycle progression, but also a critical checkpoint …

The cyclin-dependent kinase 1 (Cdk1), formerly called Cdc2 (or p34 Cdc2), interacts with
cyclin B1 to form an active heterodimer. The activity of Cdk1 is subjected to a complex …

The Cdc25 A phosphatase is required for the G 1–S transition of the cell cycle and is
overexpressed in human cancers. We found that it is ubiquitylated and rapidly degraded by …

Cdc42Hs is a small GTPase of the Rho-subfamily, which regulates signaling pathways that
influence cell morphology and polarity, cell-cycle progression and transcription [1–7]. An …

Cdc48 (p97), a conserved chaperone-like ATPase of eukaryotic cells, has attracted attention
recently because of its wide range of cellular functions. Cdc48 is intimately linked to the …

The ubiquitin-conjugating enzyme Cdc34 (cell division cycle 34) plays an essential role in
promoting the G1–S-phase transition of the eukaryotic cell cycle and is phosphorylated in …

Programmed cell death (PCD) is involved in a variety of biologic events. Based on the
morphologic appearance of the cells, there are two types of PCD as follows: apoptotic (type …