The balance between cell cycle progression and apoptosis is important for both surveillance
against genomic defects and responses to drugs that arrest the cell cycle. In this report, we …

Background Blockade of mitotic progression is an ideal approach to induce mitotic
catastrophe that suppresses cancer cell expansion. Cdc20 is a critical mitotic factor …

Rho-GTPases control a variety of cellular functions mainly by regulating microtubule and
actin dynamics, affecting the cytoskeleton, and are important regulators of the structural …

Entry into and progression through mitosis depends on phosphorylation and
dephosphorylation of key substrates. In yeast, the nucleolar phosphatase Cdc14 is pivotal …

Alterations in the cell-cycle regulatory genes result in uncontrolled cell proliferation leading
to several disease conditions. Cyclin-dependent kinases (CDK) and their regulatory subunit …

Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome
segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) …

Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it
controls the correct segregation of chromosomes during mitosis. Many studies have focused …

The ubiquitin-conjugating enzyme, CDC34, has been implicated in the ubiquitination of a
number of vertebrate substrates, including p27 Kip1, IκBα, Wee1, and MyoD. We show that …

Missense mutations of valosin-containing protein (VCP) cause an autosomal dominant
disease known as inclusion body myopathy, Paget disease with frontotemporal dementia …

Cdc25 phosphatases propel cell cycle progression by activating cyclin-dependent kinases
(Cdk). DNA damage is generally thought to inhibit Cdc25 functionality by inducing …