NME Digest highlights new, biologically active molecules revealed for the first time in current
literature, at congresses and in company communications that are identified by a code …

Background and Purpose TRPM4 is a calcium‐activated non‐selective cation channel
expressed in many tissues and implicated in several diseases, and has not yet been …

Highlights•The structures and gating mechanisms of the TRPM2 channel are outlined.•The
reported TRPM2 inhibitors and their inhibitory properties are summarized.•The therapeutic …

QPatch HT is an automated patch clamp system with high data quality/content and greatly
increased throughput over conventional patch clamp methods. To determine whether this …

Transient receptor potential melastatin type 8 (TRPM8) is a target for the treatment of
different physio-pathological processes. While TRPM8 antagonists are reported as potential …

Abstract Transient Receptor Potential Melastatin 5 (TRPM5) is an intracellular calcium-
activated cation-selective ion channel expressed in a variety of cell types. Dysfunction of this …

This publication details the discovery of a series of selective transient receptor potential
cation channel subfamily M member 5 (TRPM5) agonists culminating with the identification …

Transient receptor potential melastatin 2 (TRPM2), a Ca 2+-permeable cationic channel,
plays critical roles in insulin release, cytokine production, body temperature regulation and …

A series of benzothiophene-based phosphonates was synthesized and many analogs within
the series were shown to be potent antagonists of the TRPM8 channel. The compounds …

The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly
expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays …