Aims Thyroid hormone (TH) rapidly relaxes vascular smooth muscle cells (VSMCs).
However, the mechanisms involved in this effect remain unclear. We hypothesize that TH …

Abstract Background/Aims: Vascular relaxation caused by Triiodothyronine (T3) involves
direct activation of endothelial cells (EC) and vascular smooth muscle cells (VSMC) …

Objective: Hyperthyroidism has pronounced effects on vascular function and endothelium-
dependent relaxation. The aim of the present study was to identify mechanisms underlying …

Thyroid hormone (TH) treatment exerts beneficial effects on the cardiovascular system: it
lowers cholesterol and LDL levels and enhances cardiac contractile function. However, little …

Hyperthyroidism is characterized by increased vascular relaxation and decreased vascular
contraction and is associated with augmented levels of triiodothyronine (T3) that contribute …

Thyroid disease has profound effects on cardiovascular function. Hypo-and hyperthyroidism,
for example, are associated with reduced and increased maximal endothelium-dependent …

The enhanced cardiovascular hemodynamics associated with triiodo-l-thyronine (T3)
treatment is in part mediated by a decrease in systemic vascular resistance. To determine …

Background: Thyroid hormone (TH) plays an important role in the modulation of cardiac
function, including contractility and systemic vascular resistance (SVR). 3, 5, 3 …

Signaling via endothelial nitric oxide synthase (NOS3) limits the heart's response to β-
adrenergic (β-AR) stimulation, which may be protective against arrhythmias. However …

Hypothyroidism impairs endothelium-dependent dilatations, while hyperthyroidism
augments the production of endothelial nitric oxide. Thus, experiments were designed to …