Klotho is highly expressed in the kidney and a soluble form of Klotho functions as an
endocrine substance that exerts multiple actions including the modulation of renal solute …

The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

Klotho is a single-pass transmembrane protein that is highly expressed in the kidney and is
known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

Klotho is a single-pass transmembrane protein that exerts its biological functions through
multiple modes. Membrane-bound Klotho acts as coreceptor for the major phosphatonin …

Klotho is a single-pass transmembrane protein highly expressed in the kidney. Membrane
Klotho protein acts as a co-receptor for fibroblast growth factor-23. Its extracellular domain is …

Klotho is a single‐pass transmembrane protein predominantly expressed in the kidney. The
extracellular domain of Klotho is subject to ectodomain shedding and is released into the …

Klotho in health and disease : Current Opinion in Nephrology and Hypertension Klotho in
health and disease : Current Opinion in Nephrology and Hypertension Log in or Register …

Abstract Background Soluble Klotho has multiple systemic salutary effects. In animals, both
acute and chronic kidney disease models display systemic Klotho deficiency. As such, there …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the …