BACKGROUND: Cardiomyocyte apoptosis is implicated in the pathogenesis of heart failure
and mitochondria play an important role in this mode of cell death. In this study, activity of the …

Background—Left ventricular hypertrophy (LVH) represents both an adaptive response to
increased cardiac work load and a precursor state of heart failure. Recent evidence linked …

BACKGROUND: Apoptosis has been implicated as a possible mechanism in the
development of heart failure (HF), but the mechanisms involved remain unclear. In patients …

This study examined sex differences in the regulation of pro-and anti-apoptotic proteins in
cardiac hypertrophy and heart failure due to volume overload induced by arteriovenous (AV) …

The aim of this study was to test the hypothesis that persistent myocardial apoptosis
contributes to progression of heart failure in a canine model of pacing-induced …

Cardiac myocyte apoptosis is potentially important in many cardiac disorders. In other cells,
Bcl-2 family proteins and mitochondrial dysfunction are probably key regulators of the …

Loss of myocardial cells via apoptosis has been observed in many cardiovascular diseases
and has been shown to contribute to the initiation and progression of heart failure. The Bcl-2 …

Background: Bcl-2 proto-oncogene, an inhibitor of apoptosis and Bax proto-oncogene, an
inducer of apoptosis play critical roles in the molecular circuit controlling apoptosis in …

Heart failure is known to be associated with an increase in cardiomyocyte apoptosis;
however, neither its occurrence nor the mechanisms involved in hearts failing due to volume …

The exact mechanisms responsible for the progression of heart failure remain unclear. We
investigated the in vivo relationship between the incidence of apoptotic cell death and left …