Significance: Stress granules (SGs) are biomolecular condensates that form upon global
translation suppression during stress. SGs are enriched in translation factors and …

Stress granule formation is triggered by the release of mRNAs from polysomes and is
promoted by the action of the RNA-binding proteins G3BP1/2. Stress granules have been …

Stress granules are membraneless protein-and mRNA-rich organelles that form in response
to perturbations in environmental conditions. Stress granule formation is reversible, and …

Stress granules (SGs) assemble under stress-induced conditions that inhibit protein
synthesis, including phosphorylation of eIF2α, inhibition of the RNA helicase eIF4a proteins …

Stress granules and P-bodies are cytosolic biomolecular condensates that dynamically form
by the phase separation of RNAs and proteins. They participate in translational control and …

Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD).
PrLDs are low-complexity domains that possess a similar amino acid composition to prion …

Eukaryotic cells contain large assemblies of RNA and protein, referred to as
ribonucleoprotein (RNP) granules, which include cytoplasmic P-bodies, stress granules, and …

The polyglutamine-binding protein 1 (PQBP1) has been linked to several X-linked
intellectual disability disorders and progressive neurodegenerative diseases. While it is …

A number of neuromuscular and muscular diseases, including amyotrophic lateral sclerosis
(ALS), spinal muscular atrophy (SMA) and several myopathies, are associated to mutations …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
heavily burdens healthcare systems worldwide. There is a significant requirement to …