Background Despite reported antiproliferative activity of vitamin A and its common use for
cancer, there is no comprehensive synthesis of its safety and efficacy in lung cancers. To …

Lung cancer is the most common cancer-related death worldwide. Natural compounds have
shown high biological and pharmaceutical relevance as anticancer agents. Retinoids are …

Vitamin A is used as a generic term for all vitamin A derivatives with retinol-like biological
activity. Retinol is the main parent compound for vitamin A. It derives from carotenoids …

Lung cancer is the leading cause of cancer death in the United States. The persisting grim
lung cancer incidence and mortality figures argue powerfully for new approaches such as …

Background Lung cancer and cardiovascular disease are major causes of death in the
United States. It has been proposed that carotenoids and retinoids are agents that may …

In this review, we aim to synthesize the emerging picture of retinoids in lung cancer through
a summary of ongoing investigations in biology, chemoprevention and therapy settings, in …

BACKGROUND: Some studies have suggested a protective effect of antioxidant nutrients on
lung cancer. Observational epidemiological studies suggest an association between higher …

Carotenoids and retinol are considered biomarkers of fruits and vegetables intake, and are
of much interest because of their anti‐inflammatory and antioxidant properties; however …

Abstract Background: The Beta-Carotene and Retinol Efficacy Trial (CARET) tested the
effect of daily β-carotene (30 mg) and retinyl palmitate (25 000 IU) on the incidence of lung …

Large, randomized trials have been conducted in the primary prevention of lung cancer
using micronutrients or derivative agents for which epidemiological data suggested a …