Induced and natural regulatory T cells in the development of inflammatory bowel disease

CG Mayne, CB Williams - Inflammatory bowel diseases, 2013 - academic.oup.com
The mucosal immune system mediates contact between the host and the trillions of
microbes that symbiotically colonize the gastrointestinal tract. Failure to tolerate the antigens …

Harnessing regulatory T cells for the treatment of inflammatory bowel disease

D Geem, A Harusato, K Flannigan… - Inflammatory bowel …, 2015 - academic.oup.com
Abstract Regulatory CD4+ T (Treg) cells are comprised of a heterogeneous population of
cells that play a vital role in suppressing inflammation and maintaining immune tolerance …

Regulatory T cells in inflammatory bowel disease

EK Boden, SB Snapper - Current opinion in gastroenterology, 2008 - journals.lww.com
Regulatory T cells in inflammatory bowel disease : Current Opinion in Gastroenterology
Regulatory T cells in inflammatory bowel disease : Current Opinion in Gastroenterology Log in …

[HTML][HTML] Promises and paradoxes of regulatory T cells in inflammatory bowel disease

JD Lord - World Journal of Gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Since their discovery two decades ago, CD4+ CD25+ Foxp3+ regulatory T cells (Tregs)
have become the subject of intense investigation by immunologists. Unlike other T cells …

[HTML][HTML] Control of intestinal inflammation by regulatory T cells

C Toms, F Powrie - Microbes and infection, 2001 - Elsevier
Regulatory T (Treg)-cell populations have been identified in a number of disease models. In
this review we focus on the role of naturally occurring Treg cells in the control of intestinal …

Regulatory T cells as a therapeutic approach for inflammatory bowel disease

M Laukova, A Glatman Zaretsky - European Journal of …, 2023 - Wiley Online Library
Abstract Foxp3+ T regulatory (Treg) cells suppress inflammation and are essential for
maintaining tissue homeostasis. A growing appreciation of tissue‐specific Treg functions …

Functional heterogeneity of gut‐resident regulatory T cells

M Luu, U Steinhoff, A Visekruna - Clinical & translational …, 2017 - Wiley Online Library
Regulatory T cells (Treg cells) have a central role in the maintenance of intestinal
homeostasis by restraining inappropriate immune responses in the healthy gut. Although …

Controlling the frontier: regulatory T-cells and intestinal homeostasis

J Bollrath, FM Powrie - Seminars in immunology, 2013 - Elsevier
The intestine represents one of the most challenging sites for the immune system as immune
cells must be able to mount an efficient response to invading pathogens while tolerating the …

Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease

D Ishikawa, A Okazawa, D Corridoni, LG Jia… - Mucosal …, 2013 - nature.com
Although regulatory T cells (Tregs) have been implicated in inflammatory bowel disease,
Tregs from Crohn's disease (CD) patients are increased in number and function normally in …

Intestinal regulatory T cells as specialized tissue-restricted immune cells in intestinal immune homeostasis and disease

J Jacobse, J Li, EHHM Rings, JN Samsom… - Frontiers in …, 2021 - frontiersin.org
FOXP3+ regulatory T cells (Treg cells) are a specialized population of CD4+ T cells that
restrict immune activation and are essential to prevent systemic autoimmunity. In the …