[HTML][HTML] A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …
[HTML][HTML] Framingham Heart Study genome-wide association: results for pulmonary function measures
Background Pulmonary function measures obtained by spirometry are used to diagnose
chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted …
chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted …
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function
Background: Smoking is the strongest environmental risk factor for reduced pulmonary
function. The genetic component of various pulmonary traits has also been demonstrated …
function. The genetic component of various pulmonary traits has also been demonstrated …
The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility
PJ Castaldi, MH Cho, AA Litonjua, P Bakke… - American journal of …, 2011 - atsjournals.org
Two recent metaanalyses of genome-wide association studies conducted by the CHARGE
and SpiroMeta consortia identified novel loci yielding evidence of association at or near …
and SpiroMeta consortia identified novel loci yielding evidence of association at or near …
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers
Rationale: Previous studies of chronic obstructive pulmonary disease (COPD) have
suggested that genetic factors play an important role in the development of disease …
suggested that genetic factors play an important role in the development of disease …
Interaction of cigarette smoking and polygenic risk score on reduced lung function
Importance The risk of airflow limitation and chronic obstructive pulmonary disease (COPD)
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
[HTML][HTML] Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function
Genome-wide association studies have identified numerous genetic loci for spirometic
measures of pulmonary function, forced expiratory volume in one second (FEV1), and its …
measures of pulmonary function, forced expiratory volume in one second (FEV1), and its …
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …
[HTML][HTML] Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease
Chronic obstructive pulmonary disease (COPD) independently associates with an increased
risk of coronary artery disease (CAD), but it has not been fully investigated whether this co …
risk of coronary artery disease (CAD), but it has not been fully investigated whether this co …
A genome-wide association study in Hispanics/Latinos identifies novel signals for lung function. The Hispanic Community Health Study/Study of Latinos
Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable
traits. Genome-wide association studies (GWAS) have identified numerous pulmonary …
traits. Genome-wide association studies (GWAS) have identified numerous pulmonary …