A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample
Rationale Lung function measures are heritable traits that predict population morbidity and
mortality and are essential for the diagnosis of chronic obstructive pulmonary disease …
mortality and are essential for the diagnosis of chronic obstructive pulmonary disease …
Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease
LJ Palmer, JC Celedón, HA Chapman… - Human molecular …, 2003 - academic.oup.com
Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated
with significant and increasing morbidity and mortality. The cardinal feature of COPD is …
with significant and increasing morbidity and mortality. The cardinal feature of COPD is …
[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …
Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema
Background There is notable heterogeneity in the clinical presentation of patients with
COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by …
COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by …
A genome-wide association study of pulmonary function measures in the Framingham Heart Study
The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
measure used to diagnose airflow obstruction and is highly heritable. We performed a …
Genome-wide association study identifies five loci associated with lung function
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
Genome-wide association study of lung function decline in adults with and without asthma
M Imboden, E Bouzigon, I Curjuric, A Ramasamy… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Genome-wide association studies have identified determinants of chronic
obstructive pulmonary disease, asthma, and lung function level; however, none have …
obstructive pulmonary disease, asthma, and lung function level; however, none have …
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated
with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; …
with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; …
Genome-wide association study of smoking behaviours in patients with COPD
Background Cigarette smoking is a major risk factor for chronic obstructive pulmonary
disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) …
disease (COPD) and COPD severity. Previous genome-wide association studies (GWAS) …