Risk of chronic obstructive pulmonary disease (COPD) is determined by both cigarette
smoking and genetic susceptibility, but little is known about gene-by-smoking interactions …

Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …

Lack of reproducibility of findings has been a criticism of genetic association studies on
complex diseases, such as chronic obstructive pulmonary disease (COPD). We selected …

Rationale: We classified individuals into pulmonary disease subtypes based on 2 underlying
pathophysiologic disease axes (airway-predominant and emphysema-predominant) and …

Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung
function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are …

There is considerable variability in the susceptibility of smokers to develop chronic
obstructive pulmonary disease (COPD). The only known genetic risk factor is severe …

Prior studies have found cross-sectional lung function to be highly heritable. In the present
study, we used a 10-cM genome-wide scan of 1,578 members of 330 families participating …

Background Lung function is a heritable complex phenotype with obesity being one of its
important risk factors. However, knowledge of their shared genetic basis is limited. Most …

Background A growing number of studies clearly demonstrate a substantial association
between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases …

Background Genome-wide association studies (GWAS) have identified numerous loci
influencing cross-sectional lung function, but less is known about genes influencing …