Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease
Rationale: Genome-wide association studies have shown significant associations between
variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic …
variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic …
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
[HTML][HTML] Common genetic polymorphisms influence blood biomarker measurements in COPD
Implementing precision medicine for complex diseases such as chronic obstructive lung
disease (COPD) will require extensive use of biomarkers and an in-depth understanding of …
disease (COPD) will require extensive use of biomarkers and an in-depth understanding of …
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility
Cigarette smoking is the major environmental risk factor for chronic obstructive pulmonary
disease (COPD). Genome-wide association studies have provided compelling associations …
disease (COPD). Genome-wide association studies have provided compelling associations …
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
M Soler Artigas, LV Wain, E Repapi… - American journal of …, 2011 - atsjournals.org
Rationale: Genomic loci are associated with FEV1 or the ratio of FEV1 to FVC in population
samples, but their association with chronic obstructive pulmonary disease (COPD) has not …
samples, but their association with chronic obstructive pulmonary disease (COPD) has not …
[HTML][HTML] Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population
I Curjuric, M Imboden, R Nadif, A Kumar, C Schindler… - PloS one, 2012 - journals.plos.org
Background Oxidative stress related genes modify the effects of ambient air pollution or
tobacco smoking on lung function decline. The impact of interactions might be substantial …
tobacco smoking on lung function decline. The impact of interactions might be substantial …
CHRNA3/5, IREB2, and ADCY2 Are Associated with Severe Chronic Obstructive Pulmonary Disease in Poland
We examined the association between single-nucleotide polymorphisms (SNPs) previously
associated with chronic obstructive pulmonary disease (COPD) and/or lung function with …
associated with chronic obstructive pulmonary disease (COPD) and/or lung function with …
A genome-wide association study of emphysema and airway quantitative imaging phenotypes
Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of
airflow limitation on spirometry, yet subjects with COPD can have marked differences in …
airflow limitation on spirometry, yet subjects with COPD can have marked differences in …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …