Genome-wide association analysis identifies six new loci associated with forced vital capacity
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung
volume and is used to diagnose and monitor lung diseases. We performed genome-wide …
volume and is used to diagnose and monitor lung diseases. We performed genome-wide …
A genetic risk score associated with chronic obstructive pulmonary disease susceptibility and lung structure on computed tomography
EC Oelsner, VE Ortega, BM Smith… - American journal of …, 2019 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with
numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in …
numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
Genetic risk factors for the development of pulmonary disease identified by genome‐wide association
Chronic respiratory diseases are a major cause of morbidity and mortality. Asthma and
chronic obstructive pulmonary disease (COPD) combined affect over 500 million people …
chronic obstructive pulmonary disease (COPD) combined affect over 500 million people …
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …
chronic obstructive pulmonary disease. We tested genome-wide association with forced …
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association …
and is the third leading cause of death globally. Through genome-wide association …
A genome-wide association study of chronic obstructive pulmonary disease in Hispanics
Rationale: Genome-wide association studies (GWAS) of chronic obstructive pulmonary
disease (COPD) have identified disease-susceptibility loci, mostly in subjects of European …
disease (COPD) have identified disease-susceptibility loci, mostly in subjects of European …
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene
Abstract Background Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced
FEV 1 in the setting of a preserved FEV 1/FVC ratio, is highly prevalent and is associated …
FEV 1 in the setting of a preserved FEV 1/FVC ratio, is highly prevalent and is associated …
Heritability of pulmonary function estimated from pedigree and whole-genome markers
YC Klimentidis, AI Vazquez, G de Los Campos… - Frontiers in …, 2013 - frontiersin.org
Asthma and chronic obstructive pulmonary disease (COPD) are major worldwide health
problems. Pulmonary function testing is a useful diagnostic tool for these diseases, and is …
problems. Pulmonary function testing is a useful diagnostic tool for these diseases, and is …
Updates on the COPD gene list
Y Bossé - International journal of chronic obstructive pulmonary …, 2012 - Taylor & Francis
A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …
established. However, the specific genes responsible for enhanced risk or host differences …