Rationale: A genome-wide association study (GWAS) for circulating chronic obstructive
pulmonary disease (COPD) biomarkers could identify genetic determinants of biomarker …

Background Blood biomarkers are increasingly used to stratify high risk chronic obstructive
pulmonary disease (COPD) patients; however, there are fewer studies that have …

Abstract The COPD Genetic Epidemiology (COPDGene®) study provides a rich cross-
sectional dataset of patients with substantial tobacco smoke exposure, varied by race …

The heritability of chronic obstructive pulmonary disease (COPD) cannot be fully explained
by recognized genetic risk factors identified as achieving genome-wide significance. In …

Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease;
however, there are few studies on the associations of cardiovascular genes with COPD. We …

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Inducible heme oxygenase (HO-1) acts against oxidants that are thought to play a major role
in the pathogenesis of chronic obstructive pulmonary disease (COPD), characterised by …

Background Recent meta-analyses of genome-wide association studies in general
populations of European descent have identified 28 loci for lung function. Objective We …

Spirometric measures of pulmonary function exhibited high heritability in the National Heart,
Lung, and Blood Institute Family Heart Study. A genome scan of FEV1, FVC, and the ratio of …

Background: COPDGene is a multicenter observational study designed to identify genetic
factors associated with COPD. It will also characterize chest CT phenotypes in COPD …