Significant spirometric transitions and preserved ratio impaired spirometry among ever smokers
Background Emerging data from longitudinal studies suggest that preserved ratio impaired
spirometry (PRISm), defined by proportionate reductions in FEV 1 and FVC, is a …
spirometry (PRISm), defined by proportionate reductions in FEV 1 and FVC, is a …
A novel spirometric measure identifies mild COPD unidentified by standard criteria
Background In chronic obstructive pulmonary disease, both smaller and larger airways are
affected. FEV 1 mainly reflects large airways obstruction, while the later fraction of forced …
affected. FEV 1 mainly reflects large airways obstruction, while the later fraction of forced …
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Results We undertook a meta-analysis of 17 GWAS imputed using the 1000 Genomes
Project 18 Phase-1 reference panel in a study of 38,199 individuals of European ancestry in …
Project 18 Phase-1 reference panel in a study of 38,199 individuals of European ancestry in …
Phenotype of spirometric impairment in an aging population
CA Vaz Fragoso, G McAvay, PH Van Ness… - American journal of …, 2016 - atsjournals.org
Rationale: The Global Lung Initiative (GLI) provides age-appropriate criteria for establishing
spirometric impairment, including mild, moderate, and severe chronic obstructive pulmonary …
spirometric impairment, including mild, moderate, and severe chronic obstructive pulmonary …
Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study
Background Childhood asthma is strongly influenced by genetics and is a risk factor for
reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This …
reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This …
Smoking and Genetic Risk Variation Across Populations of E uropean, A sian, and A frican A merican Ancestry—A Meta‐Analysis of Chromosome 15q25
LS Chen, NL Saccone, RC Culverhouse… - Genetic …, 2012 - Wiley Online Library
Recent meta‐analyses of E uropean ancestry subjects show strong evidence for association
between smoking quantity and multiple genetic variants on chromosome 15q25. This meta …
between smoking quantity and multiple genetic variants on chromosome 15q25. This meta …
[HTML][HTML] Meta-analysis of exome array data identifies six novel genetic loci for lung function
Background: function to date, many of which have also been implicated in chronic
obstructive pulmonary disease. We carried out meta-analyses of exome array data and three …
obstructive pulmonary disease. We carried out meta-analyses of exome array data and three …
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of
European ancestry populations. We extend previous research by meta-analyzing genome …
European ancestry populations. We extend previous research by meta-analyzing genome …
Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD
Accelerated lung function decline is a key COPD phenotype; however, its genetic control
remains largely unknown. We performed a genome-wide association study using the …
remains largely unknown. We performed a genome-wide association study using the …
Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A
DA van der Plaat, K de Jong, L Lahousse, A Faiz… - Journal of Allergy and …, 2017 - Elsevier
Background Although a striking proportion (25% to 45%) of patients with chronic obstructive
pulmonary disease are never-smokers, most genetic susceptibility studies have not focused …
pulmonary disease are never-smokers, most genetic susceptibility studies have not focused …