Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …

Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …

Background: The early phase of Alzheimer's disease (AD) involves the disruption of finely
tuned neuronal circuitry in brain regions associated with learning and memory. This tuning is …

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

Synaptic dysfunction and disconnectivity are core deficits in Alzheimer's disease (AD),
preceding clear changes in histopathology and cognitive functioning. Here, the early and …

The early stages of Alzheimer's disease (AD) have been linked to microcircuit dysfunction
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

Alzheimer's disease (AD) is the commonest neurodegenerative disease with slow
progression. Pieces of evidence suggest that the GABAergic system is impaired in the early …

Neurodegenerative diseases, including Alzheimer's disease (AD), target specific and
functionally connected neuronal networks, raising the possibility that neurodegeneration …

Background Neuronal hyperactivity related to β-amyloid (Aβ) is considered an early warning
sign of Alzheimer disease (AD). Although increasing evidence supports this opinion, the …