Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
RS Hotchkiss, PE Swanson, BD Freeman… - Critical care …, 1999 - journals.lww.com
Objectives The purpose of this study was to determine whether apoptosis is a major
mechanism of cell death in patients with sepsis. The activities of caspase-3 and the …
mechanism of cell death in patients with sepsis. The activities of caspase-3 and the …
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice
CM Coopersmith, KC Chang, PE Swanson… - Critical care …, 2002 - journals.lww.com
Objectives The aim of this study was to determine whether decreasing intestinal epithelial
apoptosis in sepsis would alter mortality rates. The roles of the antiapoptotic protein Bcl-2 …
apoptosis in sepsis would alter mortality rates. The roles of the antiapoptotic protein Bcl-2 …
Rapid onset of intestinal epithelial and lymphocyte apoptotic cell death in patients with trauma and shock
RS Hotchkiss, RE Schmieg Jr, PE Swanson… - Critical care …, 2000 - journals.lww.com
Objective Apoptosis is a cellular suicide program that can be activated by cell injury or
stress. Although a number of laboratory studies have shown that ischemia/reperfusion injury …
stress. Although a number of laboratory studies have shown that ischemia/reperfusion injury …
Apoptosis in sepsis
R Mahidhara, TR Billiar - Critical care medicine, 2000 - journals.lww.com
Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …
infection. Previous models have focused on the mechanisms which upregulate and sustain …
Cellular apoptosis and organ injury in sepsis: a review
C Power, N Fanning, HP Redmond - Shock, 2002 - journals.lww.com
Apoptosis, as a biological phenomenon, is readily identifiable by several characteristic
features. It characteristically affects scattered single cells, not groups of contiguous cells as …
features. It characteristically affects scattered single cells, not groups of contiguous cells as …
Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T-and B-cell-deficient mice
RS Hotchkiss, PE Swanson, JP Cobb… - Critical care …, 1997 - journals.lww.com
Objectives To determine if apoptosis (programmed cell death) occurs systemically in
lymphoid and parenchymal cells during sepsis. To examine the potential role of T and B …
lymphoid and parenchymal cells during sepsis. To examine the potential role of T and B …
Role of apoptotic cell death in sepsis
RS Hotchkiss, KW Tinsley, IE Karl - Scandinavian journal of …, 2003 - Taylor & Francis
Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …
Apoptosis in sepsis: a new target for therapeutic exploration
C Oberholzer, A Oberholzer, M Clare-Salzler… - The FASEB …, 2001 - Wiley Online Library
The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …
prospective trials with biological response modifiers aimed at the inflammatory response …
Mechanisms of organ dysfunction in critical illness: report from a Round Table Conference held in Brussels
MP Fink, TW Evans - Intensive care medicine, 2002 - Springer
The most common cause of death in patients with sepsis or other forms of critical illness is
deterioration in the function of multiple organs, now termed multiple organ dysfunction …
deterioration in the function of multiple organs, now termed multiple organ dysfunction …
Prevention of lymphocyte apoptosis—a potential treatment of sepsis?
RS Hotchkiss, CM Coopersmith… - Clinical Infectious …, 2005 - academic.oup.com
Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …
morbidity and mortality in neonatal and medical intensive care units. The Centers for …
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