Objectives The purpose of this study was to determine whether apoptosis is a major
mechanism of cell death in patients with sepsis. The activities of caspase-3 and the …

Objectives The aim of this study was to determine whether decreasing intestinal epithelial
apoptosis in sepsis would alter mortality rates. The roles of the antiapoptotic protein Bcl-2 …

Objective Apoptosis is a cellular suicide program that can be activated by cell injury or
stress. Although a number of laboratory studies have shown that ischemia/reperfusion injury …

Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …

Apoptosis, as a biological phenomenon, is readily identifiable by several characteristic
features. It characteristically affects scattered single cells, not groups of contiguous cells as …

Objectives To determine if apoptosis (programmed cell death) occurs systemically in
lymphoid and parenchymal cells during sepsis. To examine the potential role of T and B …

Sepsis is the leading cause of morbidity and mortality in critically ill patients in many
intensive care units. The pathophysiology of organ failure and death in patients with sepsis …

The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …

The most common cause of death in patients with sepsis or other forms of critical illness is
deterioration in the function of multiple organs, now termed multiple organ dysfunction …

Sepsis is the leading cause of death in surgical intensive care units and is a major cause of
morbidity and mortality in neonatal and medical intensive care units. The Centers for …