Haemodynamic effects and pharmacokinetics of oral d-and l-nebivolol in hypertensive patients

A Himmelmann, T Hedner, E Snoeck… - European journal of …, 1996 - Springer
Objective: Nebivolol is a selective β 1-adrenergic receptor blocker possessing an ancillary
vasodilating effect. The objective of the present study was to study the haemodynamic and …

Nebivolol: impact on cardiac and endothelial function and clinical utility

JE Toblli, F DiGennaro, JF Giani… - Vascular Health and …, 2012 - Taylor & Francis
Endothelial dysfunction is a systemic pathological state of the endothelium characterized by
a reduction in the bioavailability of vasodilators, essentially nitric oxide, leading to impaired …

Nebivolol: more than a highly selective Beta blocker

Y Karter - Recent Patents on Cardiovascular Drug Discovery …, 2007 - ingentaconnect.com
Although their specific mechanisms of action are incompletely understood, beta blockers are
most likely lower blood pressure and provide target organ protection by several different …

Efficacy and tolerability of nebivolol in stage I–II hypertension: a pooled analysis of data from three randomized, placebo-controlled monotherapy trials

RJ Weiss, E Saunders, M Greathouse - Clinical therapeutics, 2011 - Elsevier
BACKGROUND: Nebivolol is a β1-selective β-blocker with NO-mediated vasodilatory
properties, approved in the United States for the treatment of stage I–II hypertension …

Nebivolol Monotherapy in Younger Adults (Younger Than 55 Years) With Hypertension: A Randomized, Placebo‐Controlled Trial

TD Giles, BV Khan, J Lato, L Brener… - The Journal of …, 2013 - Wiley Online Library
Nebivolol, a vasodilatory β1‐blocker, may be well suited for the hemodynamics of the
younger hypertensive patient. In this 8‐week trial, 18‐to 54‐year‐olds with a diastolic blood …

Use of nebivolol for the treatment of endothelial dysfunction in patients with hypertension: the EDEN registry

O Masoli, M Redruello, NP Baliño… - Journal of …, 2008 - journals.lww.com
This aim of this study was to evaluate the presence of endothelial dysfunction in patients
with primary hypertension and to determine the usefulness of nebivolol, a selective β …

[HTML][HTML] Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study

RO Vaz-de-Melo, LT Giollo-Júnior… - São Paulo medical …, 2014 - SciELO Brasil
CONTEXT AND OBJECTIVES: Assessment of central blood pressure (BP) has grown
substantially over recent years because evidence has shown that central BP is more …

Metabolic profile of nebivolol, a β-adrenoceptor antagonist with unique characteristics

EA Rosei, D Rizzoni - Drugs, 2007 - Springer
Abstract β-Adrenoceptor antagonists (β-blockers) have historically been considered an
effective and safe option for first-line treatment of hypertension. However, very recently, it …

[HTML][HTML] Beneficial effects of nebivolol in comparison with atenolol on safety and tolerability in essential hypertension

VV Bhosale, SC Inamdar, VB Karande… - Journal of clinical and …, 2014 - ncbi.nlm.nih.gov
Abstract Introduction: Hypertension,“The silent killer” is a multifactorial disorder which is
asymptomatic and if left untreated leads to lethal complications. Nebivolol is a third …

Clinical pharmacokinetics of nebivolol: a systematic review

N Hanif, A Zamir, I Imran, H Saeed… - Drug Metabolism …, 2023 - Taylor & Francis
Nebivolol is a beta-1 receptor blocker used to treat hypertension, heart failure, erectile
dysfunction, vascular disease, and diabetes mellitus. This review investigated the data …