The amide linkage is generally considered to make amides the most stable carboxylic acid
derivatives, and this is one feature that contributes to their attractiveness as building blocks …

Human β‐defensins (HBDs) are cationic antimicrobial peptides constrained by three
disulfide bridges. They have diverse range of functions in the innate immune response. It is …

A series of engineered linear analogues [coded as F6, W6, Y6, A6, S6 and C (Acm) 6] were
modeled, designed, synthesized and structurally characterized by mass spectra, circular …

Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and
high serum stability, which is useful to develop and design novel antimicrobial agents …

We have designed a cyclic 17-amino acid β-defensin analog featuring a single disulfide
bond. This analog, designated “AMC”(ie, antimicrobial cyclic peptide), combines the internal …

Microbial resistance against clinical used antibiotics is on the rise. Accordingly, there is a
high demand for new innovative antimicrobial strategies. The host-defense peptide human …

ABSTRACT β-Defensins are known to be both antimicrobial and able to chemoattract
various immune cells. Although the sequences of paralogous genes are not highly …

Peptide and protein thioesters are playing an increasingly prominent role in the chemical
toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In …

Highlights•Reversible covalent chemistry and peptide dynamic combinatorial libraries.•
Chemoselective reversible amide bond and peptide bond forming reactions.•Peptide …

Abstract Human α-defensin 5 (DEF5), expressed by the Paneth cells of human small
intestine, plays an important role in host defense against microbial infections. DEF5, a 32 …