Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments

E Lou, P O'Hare, S Subramanian, CJ Steer - The FEBS journal, 2017 - Wiley Online Library
Tunneling nanotubes (TNT s) are membranous conduits for direct cell‐to‐cell
communication. Until the past decade, little had been known about their composite structure …

[HTML][HTML] Opportunities and challenges in tunneling nanotubes research: how far from clinical application?

X Han, X Wang - International journal of molecular sciences, 2021 - mdpi.com
Tunneling nanotubes (TNTs) are recognized long membrane nanotubes connecting
distance cells. In the last decade, growing evidence has shown that these subcellular …

Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications

R Mittal, E Karhu, JS Wang, S Delgado… - Journal of cellular …, 2019 - Wiley Online Library
Intercellular communication is essential for the development and maintenance of
multicellular organisms. Tunneling nanotubes (TNTs) are a recently recognized means of …

Peering into tunneling nanotubes—The path forward

D Cordero Cervantes, C Zurzolo - The EMBO journal, 2021 - embopress.org
Abstract The identification of Tunneling Nanotubes (TNTs) and TNT‐like structures signified
a critical turning point in the field of cell‐cell communication. With hypothesized roles in …

[HTML][HTML] Molecular profiles of tunneling nanotubes (TNTs) in human diseases-from 2D cultures to complex tissue

N Resnik, G Levallet, M Errede, F Re… - Frontiers in Cell and …, 2024 - frontiersin.org
4 Conclusion Supported by recent studies that have clarified many of the biological,
biomechanical, and pharmacological aspects of TNTs, these studies further extend the …

Emerging physiological and pathological implications of tunneling nanotubes formation between cells

S Sisakhtnezhad, L Khosravi - European journal of cell biology, 2015 - Elsevier
Cell-to-cell communication is a critical requirement to coordinate behaviors of the cells in a
community and thereby achieve tissue homeostasis and conservation of the multicellular …

[HTML][HTML] Tunneling Nanotube: An Enticing Cell–Cell Communication in the Nervous System

S Dagar, S Subramaniam - Biology, 2023 - mdpi.com
Simple Summary This review highlights the role of tunneling nanotubes (TNTs) and TNT-like
structures in the nervous system. TNTs are thin, hollow plasma membrane projections that …

Tunneling nanotubes: the fuel of tumor progression?

G Pinto, C Brou, C Zurzolo - Trends in cancer, 2020 - cell.com
Tunneling nanotubes (TNTs) are thin membrane tubes connecting remote cells and allowing
the transfer of cellular content. TNTs have been reported in several cancer in vitro, ex vivo …

[HTML][HTML] Multifaceted roles of tunneling nanotubes in intercellular communication

L Marzo, K Gousset, C Zurzolo - Frontiers in physiology, 2012 - frontiersin.org
Cell-to-cell communication and exchange of materials are vital processes in multicellular
organisms during cell development, cell repair, and cell survival. In neuronal and …

Identification and characterization of tunneling nanotubes for intercellular trafficking

S Abounit, E Delage, C Zurzolo - Current protocols in cell …, 2015 - Wiley Online Library
Tunneling nanotubes (TNTs) are thin membranous channels providing direct cytoplasmic
connection between remote cells. They are commonly observed in different cell cultures and …