The receptor activator of nuclear factor-κB (RANK) protein activates various protein kinase
signaling cascades, including those involving NF-κB, mitogen-activated protein kinase …

Receptor activator of nuclear factor κ B (RANK) is a member of the tumor necrosis factor
receptor superfamily (TNFRSF) and triggers osteoclastogenesis by inducing the expression …

The receptor activator of NF-κB (RANK) and immunoreceptor tyrosine-based activation motif
(ITAM)-containing adaptors are essential factors involved in regulating osteoclast formation …

Different stimuli often activate the same intracellular signaling molecules but trigger distinct
cell responses. We explored whether or not MAPK signaling induced by macrophage colony …

The signaling pathway downstream of stimulation of receptor activator of nuclear factor κB
(RANK) by RANK ligand is crucial for osteoclastogenesis. RANK recruits TNF receptor …

Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells
and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB …

SHIP is an SH2-containing inositol-5-phosphatase expressed in hematopoietic cells. It
hydrolyzes the PI3K product PI (3, 4, 5) P 3 and blunts the PI3K-initiated signaling pathway …

Protein kinase C (PKC) family members phosphorylate a wide variety of protein targets and
are known to be involved in diverse cellular signaling pathways. However, the role of PKC in …

Osteoclast (Oc) differentiation is fundamentally controlled by receptor activator of nuclear
factor kappaB ligand (RANKL). RANKL signalling targets include mitogen-activated protein …

The E3 ubiquitin ligase TRAF6 [tumor necrosis factor (TNF) receptor (TNFR)–associated
factor 6] and the associated kinase TAK1 [transforming growth factor–β (TGF-β)–activated …