PTEN tumor suppressor network in PI3K-Akt pathway control
MM Georgescu - Genes & cancer, 2010 - journals.sagepub.com
The PI3K-Akt pathway is a major survival pathway activated in cancer. Efforts to develop
targeted therapies have not been fully successful, mainly because of extensive internal …
targeted therapies have not been fully successful, mainly because of extensive internal …
PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells
PTEN is a tumor suppressor gene that is frequently mutated in human tumors. It functions
primarily as a lipid phosphatase and plays a key role in the regulation of …
primarily as a lipid phosphatase and plays a key role in the regulation of …
PTEN/PTENP1:'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy
N Haddadi, Y Lin, G Travis, AM Simpson, NT Nassif… - Molecular cancer, 2018 - Springer
Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …
PTEN function in normal and neoplastic growth
LML Chow, SJ Baker - Cancer letters, 2006 - Elsevier
The PTEN tumor suppressor is a central negative regulator of the PI3K/AKT signaling
cascade that influences multiple cellular functions including cell growth, survival …
cascade that influences multiple cellular functions including cell growth, survival …
PTEN-deficient tumors depend on AKT2 for maintenance and survival
Loss of PTEN is a common event in many cancers and leads to hyperactivation of the PI3K–
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …
AKT signaling pathway. The mechanisms by which AKT isoforms mediate signaling to …
PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?
Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …
PTEN regulates PI (3, 4) P2 signaling downstream of class I PI3K
M Malek, A Kielkowska, T Chessa, KE Anderson… - Molecular cell, 2017 - cell.com
The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in
cancer. Class I PI3Ks synthesize the lipid messenger PI (3, 4, 5) P 3. PI (3, 4, 5) P 3 can be …
cancer. Class I PI3Ks synthesize the lipid messenger PI (3, 4, 5) P 3. PI (3, 4, 5) P 3 can be …
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
LH Saal, P Johansson, K Holm… - Proceedings of the …, 2007 - National Acad Sciences
Pathway-specific therapy is the future of cancer management. The oncogenic
phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; …
phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; …
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
IM Berenjeno, J Guillermet-Guibert… - Biochemical …, 2012 - portlandpress.com
The PI3K (phosphoinositide 3-kinase) pathway is commonly activated in cancer as a
consequence of inactivation of the tumour suppressor PTEN (phosphatase and tensin …
consequence of inactivation of the tumour suppressor PTEN (phosphatase and tensin …
PTEN genomic deletion is associated with p‐Akt and AR signalling in poorer outcome, hormone refractory prostate cancer
K Sircar, M Yoshimoto, FA Monzon… - The Journal of …, 2009 - Wiley Online Library
PTEN haploinsufficiency is common in hormone‐sensitive prostate cancer, though the
incidence of genomic deletion and its downstream effects have not been elucidated in …
incidence of genomic deletion and its downstream effects have not been elucidated in …