Background: PTEN gene loss occurs frequently in castration-resistant prostate cancer
(CRPC) and may drive progression through activation of the PI3K/AKT pathway. Here, we …

Although most oncogenic phenotypes of PTEN loss are attributed to AKT activation, AKT
alone is not sufficient to induce all of the biological activities associated with PTEN …

PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …

Hyperactivation of the PI 3-kinase/AKT pathway is a driving force of many cancers. Here we
identify the AKT-inactivating phosphatase PHLPP1 as a prostate tumor suppressor. We …

Inactivating PTEN mutations are commonly found in prostate cancer, resulting in an
increased activation of Akt. In this study, we investigate the role of PTEN deletion and protein …

The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23. 3 is a negative
regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Purpose: Analytically validated assays to interrogate biomarker status in clinical samples are
crucial for personalized medicine. PTEN is a tumor suppressor commonly inactivated in …

Abstract PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …