PTEN as a prognostic/predictive biomarker in cancer: an unfulfilled promise?
C Bazzichetto, F Conciatori, M Pallocca, I Falcone… - Cancers, 2019 - mdpi.com
Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful
enrichment, and for the selection of patients who are the most likely to benefit from a specific …
enrichment, and for the selection of patients who are the most likely to benefit from a specific …
Human cancer, PTEN and the PI-3 kinase pathway
R Parsons - Seminars in cell & developmental biology, 2004 - Elsevier
The PI-3 kinase pathway is a major driving force for human cancer. One common way of
stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor …
stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor …
Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation
Loss of the tumor suppressor Pten (phosphatase and tensin homolog deleted on
chromosome 10) is thought to mediate the majority of prostate cancers, but the molecular …
chromosome 10) is thought to mediate the majority of prostate cancers, but the molecular …
PTEN and GSK3β: key regulators of progression to androgen-independent prostate cancer
Prostate cancer (PrCa) is characterized by progression from an androgen-dependent
phenotype to one that is inevitably androgen independent (AI) and lethal. Recent evidence …
phenotype to one that is inevitably androgen independent (AI) and lethal. Recent evidence …
[HTML][HTML] Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway
LA DeGraffenried, L Fulcher, WE Friedrichs… - Annals of oncology, 2004 - Elsevier
The PTEN protein is a lipid phosphatase with putative tumor suppressing abilities, including
inhibition of the PI3K/Akt signaling pathway. Inactivating mutations or deletions of the PTEN …
inhibition of the PI3K/Akt signaling pathway. Inactivating mutations or deletions of the PTEN …
PTEN dual lipid-and protein-phosphatase function in tumor progression
Simple Summary Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a
multifunctional tumor suppressor with protein-and lipid-phosphatase activities. The …
multifunctional tumor suppressor with protein-and lipid-phosphatase activities. The …
PTEN loss as determined by clinical-grade immunohistochemistry assay is associated with worse recurrence-free survival in prostate cancer
Background PTEN is the most commonly deleted tumor suppressor gene in primary prostate
cancer (PCa) and its loss is associated with poor clinical outcomes and ERG gene …
cancer (PCa) and its loss is associated with poor clinical outcomes and ERG gene …
[HTML][HTML] Study of PTEN subcellular localization
The tumor suppressor PTEN is a key regulator of a plethora of cellular processes that are
crucial in cancer development. Through its lipid phosphatase activity PTEN suppresses the …
crucial in cancer development. Through its lipid phosphatase activity PTEN suppresses the …
Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel
U Hancox, S Cosulich, L Hanson, C Trigwell… - Molecular cancer …, 2015 - AACR
Loss of PTEN protein results in upregulation of the PI3K/AKT pathway, which appears
dependent on the PI3Kβ isoform. Inhibitors of PI3Kβ have potential to reduce growth of …
dependent on the PI3Kβ isoform. Inhibitors of PI3Kβ have potential to reduce growth of …
PTEN: from pathology to biology
ML Sulis, R Parsons - Trends in cell biology, 2003 - cell.com
The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …
importance in the development of cancer is probably underestimated. As the primary …