Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis
Z Wu, HJ Cho, GM Hampton, D Theodorescu - Neoplasia, 2009 - Elsevier
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is frequently
inactivated in metastatic prostate cancer, yet the molecular consequences of this and their …
inactivated in metastatic prostate cancer, yet the molecular consequences of this and their …
[HTML][HTML] PTEN loss detection in prostate cancer: comparison of PTEN immunohistochemistry and PTEN FISH in a large retrospective prostatectomy cohort
TL Lotan, A Heumann, SD Rico, J Hicks, K Lecksell… - Oncotarget, 2017 - ncbi.nlm.nih.gov
PTEN deletion is an established prognostic biomarker in prostate cancer. We compared
PTEN immunohistochemistry (IHC) and PTEN fluorescence in situ hybridization (FISH) in the …
PTEN immunohistochemistry (IHC) and PTEN fluorescence in situ hybridization (FISH) in the …
PTEN regulation of ERK1/2 signaling in cancer
MA Chetram, CV Hinton - Journal of Receptors and Signal …, 2012 - Taylor & Francis
Since its discovery, the tumor suppressor phosphatase and tensin homolog (PTEN) has
become a molecule with a wide spectrum of functions, which is typically meditated through …
become a molecule with a wide spectrum of functions, which is typically meditated through …
[HTML][HTML] Loss of PTEN expression is associated with increased risk of recurrence after prostatectomy for clinically localized prostate cancer
PTEN (phosphatase and tensin homolog on chromosome 10) is one of the most frequently
lost tumor suppressor genes in human cancers and it has been described in more than two …
lost tumor suppressor genes in human cancers and it has been described in more than two …
PTEN expression and function in adult cancer stem cells and prospects for therapeutic targeting
L Ciuffreda, I Falcone, UC Incani, A Del Curatolo… - Advances in biological …, 2014 - Elsevier
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a non-redundant
lipid phosphatase that restrains and fine tunes the phosphatidylinositol-3-kinase (PI3K) …
lipid phosphatase that restrains and fine tunes the phosphatidylinositol-3-kinase (PI3K) …
The complexity of PTEN: mutation, marker and potential target for therapeutic intervention
LS Steelman, FE Bertrand… - Expert opinion on …, 2004 - Taylor & Francis
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatase
that removes phosphates primarily from lipids. It has also been called mutated in multiple …
that removes phosphates primarily from lipids. It has also been called mutated in multiple …
The regulatory roles of phosphatases in cancer
J Stebbing, LC Lit, H Zhang, RS Darrington, O Melaiu… - Oncogene, 2014 - nature.com
The relevance of potentially reversible post-translational modifications required for
controlling cellular processes in cancer is one of the most thriving arenas of cellular and …
controlling cellular processes in cancer is one of the most thriving arenas of cellular and …
The role of PTEN signaling perturbations in cancer and in targeted therapy
M Keniry, R Parsons - Oncogene, 2008 - nature.com
The PTEN tumor suppressor was discovered by its homozygous deletion and other
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
mutations in cancer. Since then, PTEN has been shown to be a non-redundant …
PTEN: its deregulation and tumorigenesis
T Maehama - Biological and Pharmaceutical Bulletin, 2007 - jstage.jst.go.jp
The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a
phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and …
phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and …
Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases …
Class IA phosphoinositide 3-kinase (PI3K) p110 catalytic subunits are activated upon Src
homology 2 domain-mediated binding of their p85 regulatory subunits to tyrosine …
homology 2 domain-mediated binding of their p85 regulatory subunits to tyrosine …