PTEN and PI3K/AKT in non-small-cell lung cancer
C Pérez-Ramírez, M Cañadas-Garre… - …, 2015 - Taylor & Francis
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. In the
last years, the identification of activating EGFR mutations, conferring increased sensitivity …
last years, the identification of activating EGFR mutations, conferring increased sensitivity …
PI3K blockade by Ad-PTEN inhibits invasion and induces apoptosis in radial growth phase and metastatic melanoma cells
AL Stewart, AM Mhashilkar, XH Yang, S Ekmekcioglu… - Molecular …, 2002 - Springer
Background Melanoma is an aggressive tumor with a propensity to rapidly metastasize. The
PTEN gene encodes a phosphatase with an unusual dual specificity for proteins and lipids …
PTEN gene encodes a phosphatase with an unusual dual specificity for proteins and lipids …
The TGF-β, PI3K/Akt and PTEN pathways: established and proposed biochemical integration in prostate cancer
SJ Assinder, Q Dong, Z Kovacevic… - Biochemical …, 2009 - portlandpress.com
A key to the development of improved pharmacological treatment strategies for cancer is an
understanding of the integration of biochemical pathways involved in both tumorigenesis …
understanding of the integration of biochemical pathways involved in both tumorigenesis …
PI3K/PTEN/AKT pathway: a critical mediator of oncogenic signaling
J Paez, WR Sellers - Signal transduction in cancer, 2004 - Springer
Conclusion In conclusion, direct genetic alterations leading to deregulated PI3K/Akt
signalling are common in a significant fraction of human malignancies. The forthcoming …
signalling are common in a significant fraction of human malignancies. The forthcoming …
The PTEN protein: cellular localization and post-translational regulation
NR Leslie, N Kriplani, MA Hermida… - Biochemical Society …, 2016 - portlandpress.com
The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase
dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the …
dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the …
Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction
F Vazquez, P Devreotes - Cell Cycle, 2006 - Taylor & Francis
PTEN, one the most frequently mutated genes in human cancer, acts as a tumor suppressor
by dephosphorylating the plasma membrane lipid second messenger phosphoinositide-3, 4 …
by dephosphorylating the plasma membrane lipid second messenger phosphoinositide-3, 4 …
Interplay among PI3K/AKT, PTEN/FOXO and AR signaling in prostate cancer
The PI3K signaling pathway is activated in a majority of cancer types. It promotes
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …
tumorigenesis by regulating nutrient metabolism, cell proliferation, survival, migration, and …
The PTEN–PI3K axis in cancer
A Papa, PP Pandolfi - Biomolecules, 2019 - mdpi.com
The PI3K–AKT–mTOR signal transduction pathway regulates a variety of biological
processes including cell growth, cell cycle progression and proliferation, cellular …
processes including cell growth, cell cycle progression and proliferation, cellular …
Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer
R Mehrian-Shai, CD Chen, T Shi… - Proceedings of the …, 2007 - National Acad Sciences
PTEN is an important tumor-suppressor gene associated with many cancers. Through
expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we …
expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we …